Abstract: The Jiaozishan Nature Reserve is located on the Yunnan-Guizhou Plateau, with complex topography and landforms. The technical plan for ecological restoration of road slope should fully consider the terrain and landform characteristics of the area and the cultural attributes of the natural environment surrounding Jiaozishan. Through comparative analysis, the mechanism of ecological restoration of road slope in the reserve is studied from the aspects of mechanics and hydrology, the stability of slope body is studied from the aspects of slope rate, lithology, etc., the type and vegetation of road slope ecological restoration are reasonably selected, and the ecological restoration of road slope is introduced. The advantages and limitations of the application in the construction of Jiaozishan Nature Reserve, through the in-depth analysis of the design scheme of the road slope ecological restoration project and the in-depth analysis of the engineering examples, it is believed that the road slope ecological restoration should fully consider the natural ecological environment of the protected area, and comprehensively use structural protection and protection. Ecological protection is the key to successful restoration. We must strengthen the theoretical research on ecological restoration of road slope, and formulate relevant design specifications and inspection standards for road slope ecological restoration as soon as possible.