Abstract: The establishment of the science and technology archives of nature reserve is the important measure to effectively conserve the scientific research data and to promote the integrated management leve of nature reserve. In this study, by taking Saihanwula National Nature Reserve as the research object, the science and technology archives of the nature reserve have been initially established, which include 108 volumes of with totally753 files and the formulated 4 management methods and system.This paper gives preliminary discussion on the establishment and management of science and technology archives of nature reserve, gives summary to the technical methods of the archives establishment, gives analysis for the necessity of the establishment, and proposes the specific suggestion for the further perfection to the archives of Saihanwula Nature Reserve. The study aims to have effective preservation to the scientific research data and related materials of the nature reserve in expectation with the reliable data to make the development and protection plans for the future scientific research projects of nature reserve. And meanwhile, it will provide reference for establishment and management of science and technology archives for other nature reserves.