Abstract: The responsibility scope for soil and water loss prevention and controlling of Duxiang Expressway section from Shouwang to Hongshan is 1148.72 hm², including 1010.24 hm² of the project construction area and 138.48 hm² of the directly affected area. According to the construction design of the project and the current situation of regional soil and water loss, the influence of highway construction on soil and water loss in the project area is analyzed and evaluated, and the prevention and control measures are carried out in the project area. The analysis results show that the optimized land occupation, earthwork balance and waste disposal site layout are reasonable, the construction organization of the main project is reasonable, and the construction technology is reliable. In the construction and operation of the project, under the premise of ensuring the implementation of various soil and water conservation protection measures and measures, it will not cause serious adverse effects on soil erosion, and can promote the effective integration of social and economic resources between regions.